Teriflunomide induces a tolerogenic bias in blood immune cells of MS patients

Teriflunomide treatment reduces B cells in patients with MS

OBJECTIVE To study the immunomodulatory effect of teriflunomide on innate and adaptive immune cell populations through a pilot, open-label, observational study in a cohort of patients with relapsing-remitting MS. METHODS Blood lymphocytes were isolated from 10 patients with MS before and after 3 or 12 months of treatment. Adaptive and innate immune cell subsets were analyzed by flow cytometry...

Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells

Antithymocyte globulin (ATG) is used in the prevention of graft-versus-host disease during allogeneic hematopoietic stem cell transplantation. It is generally accepted that ATG mediates its immunosuppressive effect primarily via depletion of T cells. Here, we analyzed the impact of ATG-Fresenius (now Grafalon®) on human monocyte-derived dendritic cells (DC). ATG induced a semi-mature phenotype ...

Teriflunomide slows BVL in relapsing MS

Objective: To assess, using structural image evaluation using normalization of atrophy (SIENA), the effect of teriflunomide, a once-daily oral immunomodulator, on brain volume loss (BVL) in patients with relapsing forms of MS enrolled in the phase 3 TEMSO study. Methods: TEMSO MR scans were analyzed (study personnel masked to treatment allocation) using SIENA to assess brain volume changes betw...

Myasthenia Gravis Patients Dendritic Cells and a Regulatory Milieu in Prednisolone Treatment Induces Tolerogenic

Effect of Borage Powder on Blood Cells and Immune System

This study was conducted to compare the effects of diets Borage Powder and control (no additives diets) on broiler’s average blood cell counts and immune system on the broiler chicks. Sixty four male broiler chicks (Ross 308) randomly allocated into one of two treatments with four replicates of eight chickens based on a completely randomized block design.  Diets were include control (no additiv...